Preventative intervention for social, emotional and behavioural difficulties in toddlers and their families: A pilot study

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Preventative intervention early in life is key to interrupting trajectories toward subsequent emotional and behavioural problems later in life. This study examined the effectiveness of the Holding Hands program, an innovative program of preventative intervention aimed at improving the behavioural and emotional functioning of 12 to 48-month-old toddlers, and the wellbeing of their parents. This program seeks to synthesise the existing evidence in four ways; it incorporates both traditional Parent Management Training and Direct Coaching methods. It is intensive, significantly reducing session numbers and it explicitly addresses parental emotion regulation. The program also utilises operant learning principals in an effort to contingently reinforce behaviour that parents want to see more of, without employing exclusionary strategies in response to behavior that parents want to see less of. Thirty-one families, with a toddler who met clinical or sub-clinical cut-offs for externalising or internalising problems, were self- or externally-referred to the six- to eight-week program. Results indicated statistically significant improvement in toddler emotional and behavioural functioning, and parent well-being on a range of psychometric measures from pre- to post-treatment. Treatment gains were maintained for parents and children at follow-up. Implications of these findings for clinical practice and suggestions for future research are discussed

Entanglement trapping in a non-stationary structured reservoir

We study a single two-level atom interacting with a reservoir of modes defined by a reservoir structure function with a frequency gap. Using the pseudomodes technique, we derive the main features of a trapping state formed in the weak coupling regime. Utilising different entanglement measures we show that strong correlations and entanglement between the atom and the modes are in existence when this state is formed. Furthermore, an unexpected feature for the reservoir is revealed. In the long time limit and for weak coupling the reservoir spectrum is not constant in time.Comment: 10 pages, 16 figure

Entanglement in the adiabatic limit of a two-atom Tavis-Cummings model

We study the adiabatic limit for the sequential passage of atoms through a high-Q cavity, in the presence of frequency chirps. Despite the fact that the adiabatic approximation might be expected to fail, we were able to show that for proper choice of Stark-pulses this is not the case. Instead, a connection to the resonant limit is established, where the robust creation of entanglement is demonstrated. Recent developments in the fabrication of high-Q cavities allow fidelities for a maximally entangled state up to 97%.Comment: 12 pages, 5 figures, Submitted to Physica Scripta as part of the Proceedings of the 15th CEWQO 200

Molecular heat pump for rotational states

In this work we investigate the theory for three different uni-directional population transfer schemes in trapped multilevel systems which can be utilized to cool molecular ions. The approach we use exploits the laser-induced coupling between the internal and motional degrees of freedom so that the internal state of a molecule can be mapped onto the motion of that molecule in an external trapping potential. By sympathetically cooling the translational motion back into its ground state the mapping process can be employed as part of a cooling scheme for molecular rotational levels. This step is achieved through a common mode involving a laser-cooled atom trapped alongside the molecule. For the coherent mapping we will focus on adiabatic passage techniques which may be expected to provide robust and efficient population transfers. By applying far-detuned chirped adiabatic rapid passage pulses we are able to achieve an efficiency of better than 98% for realistic parameters and including spontaneous emission. Even though our main focus is on cooling molecular states, the analysis of the different adiabatic methods has general features which can be applied to atomic systems

Familial phenotype differences in PKD1111See Editorial, p. 344.

Familial phenotype differences in PKD1.BackgroundMutations within the PKD1 gene are responsible for the most common and most severe form of autosomal dominant polycystic kidney disease (ADPKD). Although it is known that there is a wide range of disease severity within PKD1 families, it is uncertain whether differences in clinical severity also occur among PKD1 families.MethodsTen large South Wales ADPKD families with at least 12 affected members were included in the study. From affected members, clinical information was obtained, including survival data and the presence of ADPKD-associated complications. Family members who were at risk of having inherited ADPKD but were proven to be non-affected were included as controls. Linkage and haplotype analysis were performed with highly polymorphic microsatellite markers closely linked to the PKD1 gene. Survival data were analyzed by the Kaplan–Meier method and the log rank test. Logistic regression analysis was used to test for differences in complication rates between families.ResultsHaplotype analysis revealed that each family had PKD1-linked disease with a unique disease-associated haplotype. Interfamily differences were observed in overall survival (P = 0.0004), renal survival (P = 0.0001), hypertension prevalence (P = 0.013), and hernia (P = 0.048). Individuals with hypertension had significantly worse overall (P = 0.0085) and renal (P = 0.03) survival compared with those without hypertension. No statistically significant differences in the prevalence of hypertension and hernia were observed among controls.ConclusionWe conclude that phenotype differences exist between PKD1 families, which, on the basis of having unique disease-associated haplotypes, are likely to be associated with a heterogeneous range of underlying PKD1 mutations

Brazilian Think Tanks and the Rise of Austerity Discourse

This article discusses the role of think tanks in the production of ideas guiding recent change in Brazil’s economic policy. It claims that think tanks are significant policy-making agents preparing the society for change – via their communicative discourse – but also attempting to influence the interaction between political elites – via their coordinative discourse. The polarization of think tanks’ communicative discourse in regard to austerity during two critical junctures for Brazil is analysed. Discursive institutionalism is applied in order to interpret data from four Brazilian think tanks: the Institute of Applied Economic Research, the Inter-Union Department of Statistics and Socioeconomic Studies, the Fernand Braudel Institute and the Brazilian Institute of Economy. These think tanks have very different organizational and ideological characteristics but a polarization of the discussion around austerity can be observed in the discourse of all four of them. The scale ranges from an active defence of the Brazilian development model to a full-scale endorsement of austerity

Provenance-Centered Dataset of Drug-Drug Interactions

Over the years several studies have demonstrated the ability to identify potential drug-drug interactions via data mining from the literature (MEDLINE), electronic health records, public databases (Drugbank), etc. While each one of these approaches is properly statistically validated, they do not take into consideration the overlap between them as one of their decision making variables. In this paper we present LInked Drug-Drug Interactions (LIDDI), a public nanopublication-based RDF dataset with trusty URIs that encompasses some of the most cited prediction methods and sources to provide researchers a resource for leveraging the work of others into their prediction methods. As one of the main issues to overcome the usage of external resources is their mappings between drug names and identifiers used, we also provide the set of mappings we curated to be able to compare the multiple sources we aggregate in our dataset.Comment: In Proceedings of the 14th International Semantic Web Conference (ISWC) 201

Non-Markovian dynamics in atom-laser outcoupling from a double-well Bose-Einstein condensate

We investigate the dynamics of a continuous atom laser based on the merging of independently formed atomic condensates. In a first attempt to understand the dynamics of the system, we consider two independent elongated Bose-Einstein condensates which approach each other and focus on intermediate inter-trap distances so that a two-mode model is well justified. In the framework of a mean-field theory, we discuss the quasi steady-state population of the traps as well as the energy distribution of the outcoupled atoms.Comment: 21 pages, 9 figure, to appear in J. Phys.

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

We have investigated the relationship between the stability and secreted yield of a series of mutational variants of human lysozyme (HuL) in Pichia pastoris. We show that genes directly involved in the unfolded protein response (UPR), ER-associated degradation (ERAD) and ER-phagy are transcriptionally up-regulated more quickly and to higher levels in response to expression of more highly-destabilised HuL variants and those variants are secreted to lower yield. We also show that the less stable variants are retained within the cell and may also be targeted for degradation. To explore the relationship between stability and secretion further, two different single-chain-variable-fragment (scFv) antibodies were also expressed in P. pastoris, but only one of the scFvs gave rise to secreted protein. The non-secreted scFv was detected within the cell and the UPR indicators were pronounced, as they were for the poorly-secreted HuL variants. The non-secreted scFv was modified by changing either the framework regions or the linker to improve the predicted stability of the scFv and secretion was then achieved and the levels of UPR indicators were lowered Our data support the hypothesis that less stable proteins are targeted for degradation over secretion and that this accounts for the decrease in the yields observed. We discuss the secretion of proteins in relation to lysozyme amyloidosis, in particular, and optimised protein secretion, in general